Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Antibody Isotype Switching in Vertebrates.

Results and problems in cell differentiation - 1 Jan 2015

Senger Kate, Hackney Jason, Payandeh Jian, Zarrin Ali A

Abstract excerpt

The humoral or antibody-mediated immune response in vertebrates has evolved to respond to diverse antigenic challenges in various anatomical locations. Diversification of the immunoglobulin heavy chain (IgH) constant region via isotype switching allows for remarkable plasticity in the immune response, including versatile tissue distribution, Fc receptor binding, and complement fixation. This enables antibody...

Topics

Join the communities discussing this publication.

Phylogeny
Vertebrates
Models, Genetic
Models, Immunological
Evolution, Molecular
Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin Class Switching

Immunoglobulin Isotypes

Source

Identifiers

PMID: 26537387
DOI: 10.1007/978-3-319-20819-0_13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Antibody Isotype Switching in Vertebrates.PMID 26537387Read ↗

The Immunoglobulins: New Insights, Implications, and ApplicationsSemantic proximity Read ↗

The Janus (dual) model of immunoglobulin isotype evolution: Conservation and plasticity are the defining paradigmsSemantic proximity Read ↗

Production and Function of Immunoglobulin ASemantic proximity Read ↗

A comparative overview of immunoglobulin genes and the generation of their diversity in tetrapods.Semantic proximity Read ↗

Antibody Repertoires in Fish.Semantic proximity Read ↗

Going AdaptiveSemantic proximity Read ↗

Immunoglobulin A, an Active Liaison for Host-Microbiota HomeostasisSemantic proximity Read ↗

IgY : a key isotype in antibody evolutionSemantic proximity Read ↗

Antibody Fc: Linking Adaptive and Innate ImmunitySemantic proximity Read ↗

Immunoglobulin isotype influences affinity and specificitySemantic proximity Read ↗

The Role of IgA in the Pathogenesis of IgA NephropathySemantic proximity Read ↗

Antibodies and Their Receptors: Different Potential Roles in Mucosal DefenseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.