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Article

Human immunoglobulin allotypes

1 Aug 2009

Abstract excerpt

More than twenty recombinant monoclonal antibodies are approved as therapeutics. Almost all of these are based on the whole IgG isotype format, but vary in the origin of the variable regions between mouse (chimeric), humanized mouse and fully human sequences; all of those with whole IgG format employ human constant region sequences. Currently, the opposing merits of the four IgG subclasses are considered with...

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PMID: 20073133
DOI: 10.4161/mabs.1.4.9122

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