Back to search

Article

Biochemical, structural, and functional characterization of the <i>Nocardia asteroides</i> dihydrofolate reductase: a primary target of anti-nocardiosis treatment

2026-05-29

Abstract excerpt

Nocardiosis is a human infectious disease caused by several species of Nocardia and primarily affecting the skin, lungs and central nervous system. The first line treatment is based on cotrimoxazole, combining trimethoprim and sulfamethoxazole. These two drugs target respectively the dihydrofolate synthase (DHFR) and the dihydropteroate synthase (DHPS) involved in the essential folate synthesis pathway. The occur...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
c3f3669e-41ec-5e10-9d9e-27339df3f105
DOI
10.64898/2026.05.27.728178
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Biochemical, structural, and functional characterization of the <i>Nocardia asteroides</i> dihydrofolate reductase: a primary target of anti-nocardiosis treatmentDOI 10.64898/2026.05.27.728178
In-silico structural and functional annotation of hypothetical proteins from Nocardia asteroides NCTC11293: A computational approach for novel drug target identification and therapeutic developmentSemantic proximity
Dihydrofolate Reductase as a Target for Chemotherapy in ParasitesSemantic proximity
First Three-Dimensional Structure of <i>Toxoplasma gondii</i> Thymidylate Synthase–Dihydrofolate Reductase: Insights for Catalysis, Interdomain Interactions, and Substrate ChannelingSemantic proximity
Predicting antifolate resistance in the unculturable fungal pathogen <i>Pneumocystis jirovecii</i>Semantic proximity
Mutational 'hot-spots' in mammalian, bacterial and protozoal dihydrofolate reductases associated with antifolate resistance: sequence and structural comparison.Semantic proximity
Pharmacological validation of dihydrofolate reductase as a drug target in Mycobacterium abscessusSemantic proximity
Clinical and laboratory features of Nocardia novaSemantic proximity
Deep mutational scanning of <i>Pneumocystis jirovecii</i> dihydrofolate reductase reveals allosteric mechanism of resistance to an antifolateSemantic proximity
Phylogeny of the Genus <i>Nocardia</i> Based on Reassessed 16S rRNA Gene Sequences Reveals Underspeciation and Division of Strains Classified as <i>Nocardia asteroides</i> into Three Established Species and Two Unnamed TaxonsSemantic proximity
Exploration into the origins and mobilization of di-hydrofolate reductase genes and the emergence of clinical resistance to trimethoprimSemantic proximity
Recurrent mobilization of ancestral and novel variants of the chromosomal di-hydrofolate reductase gene drives the emergence of clinical resistance to trimethoprimSemantic proximity
Genetic mutations in Cryptococcus neoformans pyrimidine salvage pathway enzymes contribute to reduced susceptibility against 5-fluorocytosineSemantic proximity
Select a neighboring publication to make it the new centre.