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Article

Independent origins and non-parallel selection signatures of triclabendazole resistance in Fasciola hepatica.

Nature communications - 27 Mar 2025

Choi Young-Jun, Rosa Bruce A, Fernandez-Baca Martha V, Ore Rodrigo A, Martin John, Ortiz Pedro, Hoban Cristian, Cabada Miguel M, Mitreva Makedonka

Abstract excerpt

Triclabendazole (TCBZ) is the primary treatment for fascioliasis, a global foodborne zoonosis caused by Fasciola hepatica. Widespread resistance to TCBZ (TCBZ-R) in livestock and a rapid rise in resistant human infections are significant concerns. To understand the genetic basis of TCBZ-R, we sequenced the genomes of 99 TCBZ-sensitive (TCBZ-S) and 210 TCBZ-R adult flukes from 146 bovine livers in Cusco, Peru. We...

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Identifiers

PMID: 40148292
DOI: 10.1038/s41467-025-57796-5
PMCID: PMC11950404

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EGFR
FST

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