Article

Depolymerizing F-actin accelerates the exit from pluripotency to enhance stem cell-derived islet differentiation

2024-10-21

Abstract excerpt

<h4>ABSTRACT</h4> In this study, we demonstrate that cytoskeletal state at the onset of directed differentiation is critical for the specification of human pluripotent stem cells (hPSCs) to all three germ layers. In particular, a polymerized actin cytoskeleton facilitates directed ectoderm differentiation, while depolymerizing F-actin promotes mesendoderm lineages. Applying this concept to a stem cell-derived isl...

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Literature Corpus work: b48edca4-5c17-5c39-a4b4-04c6d09078a8
DOI: 10.1101/2024.10.21.618465

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