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ROCKII inhibition promotes the maturation of human pancreatic beta-like cells

11 Aug 2017

Abstract excerpt

Diabetes is linked to loss of pancreatic beta-cells. Pluripotent stem cells offer a valuable source of human beta-cells for basic studies of their biology and translational applications. However, the signalling pathways that regulate beta-cell development and functional maturation are not fully understood. Here we report a high content chemical screen, revealing that H1152, a ROCK inhibitor, promotes the robust...

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PMID: 28824164
DOI: 10.1038/s41467-017-00129-y

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