Article

Doxycycline Significantly Enhances Induction of iPSCs to Endoderm by Enhancing survival via AKT Phosphorylation

2020-04-14

Abstract excerpt

Induced pluripotent stem cells (iPSCs) provide an important tool for the generation patient-derived cells including hepatocyte-like cells via developmental cues through an endoderm intermediate. However, most iPSCs fail to differentiate into endoderm, with induction resulting in apoptosis. To address this issue, we built upon published methods to develop an improved protocol with our discovery that doxycycline dra...

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Literature Corpus work: c3b4601f-5fd6-5560-b12c-a625258a74d4
DOI: 10.1101/2020.04.13.034595

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Doxycycline Significantly Enhances Induction of iPSCs to Endoderm by Enhancing survival via AKT PhosphorylationDOI 10.1101/2020.04.13.034595Read

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