Article

Polycomb Repressive Complex 2 promotes atherosclerotic plaque vulnerability

2024-12-02

Abstract excerpt

<h4>Key findings:</h4> 1. PRC2 regulates EC shear stress responses. 2. PRC2 governs Klf2/4 suppression downstream of Pcdhg. 3. High PRC2 in ASCVD-prone arterial regions suppresses Klf2/4 to promote ASCVD. 4. Athero-protective Klf2/4 induction upon PRC2 inhibition requires Notch signaling. 5. Tazemetostat, an FDA approved PRC2 inhibitor, slows ASCVD progression and improves markers of plaque stability. Atheroscler...

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Literature Corpus work: d33217c6-4799-5dd9-97fa-8215b616d183
DOI: 10.1101/2024.12.02.626505

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