Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Generation of a CRISPR/Cas9-edited Plakoglobin (JUP) knock-out (JMUi001-A-4) iPSC line to model the cardiac phenotype of arrhythmogenic cardiomyopathy.

Stem cell research - 1 Dec 2023

Walz Katharina, Janz Anna, Klopocki Eva, Gerull Brenda

Abstract excerpt

Arrhythmogenic cardiomyopathy (ACM) represents the cardiac phenotype of Naxos disease, an autosomal recessive disease with an additional cutaneous phenotype. ACM is mainly caused by mutated desmosomal proteins, which are part of cardiac adherens junctions and provide mechanical and electrical stability. Here, we generated a knock-out (KO) of the junctional protein Plakoglobin (JUP-KO; JMUi001-A-4) using the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arrhythmogenic Right Ventricular Dysplasia
Share to CRISPR-Cas Systems

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to gamma Catenin

Share to Induced Pluripotent Stem Cells

Share to Myocytes, Cardiac

Share to Phenotype

Source

Identifiers

PMID: 37995437
DOI: 10.1016/j.scr.2023.103240

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Generation of a CRISPR/Cas9-edited Plakoglobin (JUP) knock-out (JMUi001-A-4) iPSC line to model the cardiac phenotype of arrhythmogenic cardiomyopathy.PMID 37995437Read ↗

CRISPR/Cas9-edited PKP2 knock-out (JMUi001-A-2) and DSG2 knock-out (JMUi001-A-3) iPSC lines as an isogenic human model system for arrhythmogenic cardiomyopathy (ACM).Semantic proximity Read ↗

Restrictive loss of plakoglobin in cardiomyocytes leads to arrhythmogenic cardiomyopathySemantic proximity Read ↗

Understanding Arrhythmogenic Cardiomyopathy: Advances through the Use of Human Pluripotent Stem Cell Models.Semantic proximity Read ↗

Pathophysiology of arrhythmogenic cardiomyopathy.Semantic proximity Read ↗

Modeling reduced contractility and impaired desmosome assembly due to plakophilin-2 deficiency using isogenic iPS cell-derived cardiomyocytesSemantic proximity Read ↗

Derivation of human induced pluripotent stem cell line EURACi004-A from skin fibroblasts of a patient with Arrhythmogenic Cardiomyopathy carrying the heterozygous PKP2 mutation c.2569_3018del50.Semantic proximity Read ↗

Generation of human induced pluripotent stem cell line EURACi006-A and its isogenic gene-corrected line EURACi006-A-1 from an arrhythmogenic cardiomyopathy patient carrying the c.1643delG PKP2 mutation.Semantic proximity Read ↗

Naxos Disease and Related Cardio-Cutaneous SyndromesSemantic proximity Read ↗

Generation of two edited iPSCs lines by CRISPR/Cas9 with point mutations in PKP2 gene for arrhythmogenic cardiomyopathy in vitro modeling.Semantic proximity Read ↗

Lack of Plakoglobin in Epidermis Leads to KeratodermaSemantic proximity Read ↗

Apremilast improves cardiomyocyte cohesion and arrhythmia in different models for arrhythmogenic cardiomyopathySemantic proximity Read ↗

Therapeutic efficacy of AAV-mediated restoration of PKP2 in arrhythmogenic cardiomyopathySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.