Article

Analysis of association studies and inference of haplotypic phase using hidden Markov models

2010-01-01

Abstract excerpt

In this thesis I focus on the development and application of hidden Markov model (HMM) to solve problems in statistical genetics. Our method, based on a HMM, models the joint haplotype structure in the samples, where the parameters in the model are estimated by the Baum-Welch EM algorithm. Also, the model does not require pre-defined blocks or a sliding window scheme to define haplotype boundaries. Thus our method...

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Literature Corpus work: b44ed1ba-c56b-5997-8e8e-209d90078416
DOI: 10.25560/5523

Open publication

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