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Article

Constrained hidden Markov models for population-based haplotyping.

BMC bioinformatics - 3 May 2007

Landwehr Niels, Mielikäinen Taneli, Eronen Lauri, Toivonen Hannu, Mannila Heikki

Abstract excerpt

BACKGROUND: Haplotype Reconstruction is the problem of resolving the hidden phase information in genotype data obtained from laboratory measurements. Solving this problem is an important intermediate step in gene association studies, which seek to uncover the genetic basis of complex diseases. We propose a novel approach for haplotype reconstruction based on constrained hidden Markov models. Models are...

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Identifiers

PMID: 17493258
DOI: 10.1186/1471-2105-8-S2-S9
PMCID: PMC1892078

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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