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Article

Disease association tests by inferring ancestral haplotypes using a hidden markov model.

Bioinformatics (Oxford, England) - 1 Apr 2008

Su Shu-Yi, Balding David J, Coin Lachlan J M

Abstract excerpt

MOTIVATION: Most genome-wide association studies rely on single nucleotide polymorphism (SNP) analyses to identify causal loci. The increased stringency required for genome-wide analyses (with per-SNP significance threshold typically approximately 10(-7)) means that many real signals will be missed. Thus it is still highly relevant to develop methods with improved power at low type I error. Haplotype-based...

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Identifiers

PMID: 18296746
DOI: 10.1093/bioinformatics/btn071

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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