Article
Inference of haplotypic phase and missing genotypes in polyploid organisms and variable copy number genomic regions.
BMC bioinformatics - 1 Dec 2008
Su Shu-Yi, White Jonathan, Balding David J, Coin Lachlan J M
Abstract excerpt
BACKGROUND: The power of haplotype-based methods for association studies, identification of regions under selection, and ancestral inference, is well-established for diploid organisms. For polyploids, however, the difficulty of determining phase has limited such approaches. Polyploidy is common in plants and is also observed in animals. Partial polyploidy is sometimes observed in humans (e.g. trisomy 21; Down's...
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