Article
Haplotype inference using a Bayesian Hidden Markov model.
Genetic epidemiology - 1 Dec 2007
Sun Shuying, Greenwood Celia M T, Neal Radford M
Abstract excerpt
Knowledge of haplotypes is useful for understanding block structure in the genome and disease risk associations. Direct measurement of haplotypes in the absence of family data is presently impractical, and hence, several methods have been developed for reconstructing haplotypes from population data. We have developed a new population-based method using a Bayesian Hidden Markov model for the source of the...
Topics
- Bayes Theorem
- Child
- Chromosomes, Human, Pair 5
- Genotype
- Haplotypes
- Humans
- Markov Chains
- Models, Genetic
- Models, Statistical
- Mutation
- Recombination, Genetic