A hidden markov model combining linkage and linkage disequilibrium information for haplotype reconstruction and quantitative trait locus fine mapping.

Abstract excerpt

Faithful reconstruction of haplotypes from diploid marker data (phasing) is important for many kinds of genetic analyses, including mapping of trait loci, prediction of genomic breeding values, and identification of signatures of selection. In human genetics, phasing most often exploits population information (linkage disequilibrium), while in animal genetics the primary source of information is familial...

Topics

• Chromosome Mapping
• Female
• Humans
• Linkage Disequilibrium
• Male
• Markov Chains
• Models, Genetic
• Polymorphism, Single Nucleotide
• Quantitative Trait Loci