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The <i>Legionella pneumophila</i> type IVb secretion system effector BinA subverts amino acid transport to sensitize TORC1 signaling in macrophages

2025-02-20

Abstract excerpt

Legionella pneumophila is an environmental Gram-negative bacterium that parasitizes unicellular protozoa and can cause severe pulmonary infections when aerosolized bacteria are inhaled by humans. One critical aspect of Legionella pathogenesis is the establishment in the cytosol of infected macrophages of a unique ER-derived vacuole, that requires a sustained supply of host lipids during expansion. Subversion of p...

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Literature Corpus work
b4493e43-e9bb-5384-8eba-4aa4eebaaffd
DOI
10.1101/2025.02.20.639245
Open publication

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