Article

Phosphoribosyl ubiquitination of SNARE proteins regulate autophagy in Legionella infection

2025-05-19

Abstract excerpt

Legionella pneumophila is an intracellular pathogen that causes Legionnaires’ disease. The bacteria releases effector proteins some of which remodel the host autophagic-lysosomal pathways. One effector is RavZ, which delipidates ATG8 proteins, making Legionella-infected cells deficient in autophagy. Here we show that SidE effectors mediate the phosphoribosyl ubiquitination (PR-Ub) of autophagic SNARE proteins STX1...

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Literature Corpus work: def36859-3e7b-5d40-a582-031683893a7f
DOI: 10.1101/2025.05.19.654886

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