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Article

FTDP-17 tau mutations induce distinct effects on aggregation and microtubule interactions.

Biochemistry - 30 Oct 2012

Combs Benjamin, Gamblin T Chris

Abstract excerpt

FTDP-17 mutations in the tau gene lead to early onset frontotemporal dementias characterized by the pathological aggregation of the microtubule-associated protein tau. Tau aggregation is closely correlated with the progression and severity of localized atrophy of certain regions in the brain. These mutations are primarily located in or near the microtubule-binding repeat regions of tau and can have vastly...

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Identifiers

PMID: 23043292
DOI: 10.1021/bi3010818
PMCID: PMC3548947

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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