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Article

Multi-tissue integrated Mendelian randomization method identifies disease risk genes.

Briefings in bioinformatics - 3 Jul 2026

Cheng Yu, Liu Shuhan, Ruan Xinjia, Li Zhonghua, Jiang Liyun, Liu Tiantian, Yan Fangrong

Abstract excerpt

Mendelian randomization (MR) leverages genetic variants as instrumental variables to infer causal relationships between molecular traits and diseases, however, identifying the specific causal genes underlying disease risk remains challenging. Here, we present MULTI (Multi-tissue Unified Likelihood-based Transcriptomic Integration), a Bayesian MR framework that integrates genetic information across tissues to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42520158
DOI: 10.1093/bib/bbag414
PMCID: PMC13411301

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