Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence for a Contribution of the Nlgn3/Cyfip1/Fmr1 Pathway in the Pathophysiology of Autism Spectrum Disorders.

Neuroscience - 1 Oct 2020

Sledziowska Monika, Galloway James, Baudouin Stéphane J

Abstract excerpt

Autism Spectrum Disorders (ASD) are characterized by heterogeneity both in their presentation and their genetic aetiology. In order to discover points of convergence common to different cases of ASD, attempts were made to identify the biological pathways genes associated with ASD contribute to. Many of these genes were found to play a role in neuronal and synaptic development and function. Among these genes are...

Topics

Adaptor Proteins, Signal Transducing
Animals
Autism Spectrum Disorder
Carrier Proteins
Cell Adhesion Molecules, Neuronal
Disease Models, Animal
Fragile X Mental Retardation Protein
Humans
Membrane Proteins
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nerve Tissue Proteins

Neuronal Plasticity

Phenotype

Source

Identifiers

PMID: 31705895
DOI: 10.1016/j.neuroscience.2019.10.011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence for a Contribution of the Nlgn3/Cyfip1/Fmr1 Pathway in the Pathophysiology of Autism Spectrum Disorders.PMID 31705895Read ↗

Functional significance of rare neuroligin 1 variants found in autism.Semantic proximity Read ↗

Analyses of the Autism-associated Neuroligin-3 R451C Mutation in Human Neurons Reveals a Gain-of-Function Synaptic MechanismSemantic proximity Read ↗

Analyses of the autism-associated neuroligin-3 R451C mutation in human neurons reveal a gain-of-function synaptic mechanism.Semantic proximity Read ↗

Autism and the synapse: emerging mechanisms and mechanism-based therapies.Semantic proximity Read ↗

Impaired metabotropic glutamate type 5 receptor signaling in the dorsal striatum of the R451C-neuroligin 3 mouse model of Autism Spectrum DisorderSemantic proximity Read ↗

Common variants in genes of the postsynaptic FMRP signalling pathway are risk factors for autism spectrum disorders.Semantic proximity Read ↗

Synaptic protein mutations in autism.Semantic proximity Read ↗

An Autism-Associated Neuroligin-3 Mutation Affects Developmental Synapse Elimination in the Cerebellum.Semantic proximity Read ↗

Unraveling the Role of Neuroligin3 in Autism Spectrum Disorders: Pathophysiological Insights and Targeted Therapies.Semantic proximity Read ↗

SHANK3 Mutations Associated with Autism and Schizophrenia Lead to Shared and Distinct Changes in Dendritic Spine Dynamics in the Developing Mouse Brain.Semantic proximity Read ↗

<i>NLGN3</i> autism variants have distinct functional impact on synapses and sleep behavior in <i>Drosophila</i>Semantic proximity Read ↗

Effects of Fmr1 Gene Mutations on Sex Differences in Autism-Like Behavior and Dendritic Spine Development in Mice and Transcriptomic Studies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.