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Mice transgenic for human angiotensin-converting enzyme 2 provide a model for SARS coronavirus infection.

Comparative medicine - 1 Oct 2007

Yang Xiu-Hong, Deng Wei, Tong Zan, Liu Yan-Xia, Zhang Lian-Feng, Zhu Hua, Gao Hong, Huang Lan, Liu Ya-Li, Ma Chun-Mei, Xu Yan-Feng, Ding Ming-Xiao, Deng Hong-Kui, Qin Chuan

Abstract excerpt

To establish a small animal model of severe acute respiratory syndrome (SARS), we developed a mouse model of human severe acute respiratory syndrome coronavirus (SARS-CoV) infection by introducing the human gene for angiotensin-converting enzyme 2 (hACE2) (the cellular receptor of SARS-CoV), driven by the mouse ACE2 promoter, into the mouse genome. The hACE2 gene was expressed in lung, heart, kidney, and...

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PMID: 17974127

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ACE2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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