Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A mouse model of lethal respiratory dysfunction for SARS-CoV-2 infection

8 Jul 2021

Abstract excerpt

The global spread of SARS-CoV-2 has made millions ill with COVID-19 and even more from the economic fallout of this pandemic. Our quest to test new therapeutics and vaccines require small animal models that replicate disease phenotypes seen in COVID-19 cases. Rodent models of SARS-CoV-2 infection thus far have shown mild to moderate pulmonary disease; mortality, if any, has been associated with prominent signs of...

Topics

Join the communities discussing this publication.

COVID-19 Clinical Research Studies
Long-Term Effects of COVID-19
SARS-CoV-2 and COVID-19 Research

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 34246735
DOI: 10.1016/j.antiviral.2021.105138

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A mouse model of lethal respiratory dysfunction for SARS-CoV-2 infectionPMID 34246735Read ↗

Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2Semantic proximity Read ↗

Characterization of Two Heterogeneous Lethal Mouse-Adapted SARS-CoV-2 Variants Recapitulating Representative Aspects of Human COVID-19Semantic proximity Read ↗

Mouse Adapted SARS-CoV-2 protects animals from lethal SARS-CoV challengeSemantic proximity Read ↗

Highly susceptible SARS-CoV-2 model in CAG promoter–driven hACE2-transgenic miceSemantic proximity Read ↗

SARS-CoV-2 Causes Lung Infection without Severe Disease in Human ACE2 Knock-In Mice.Semantic proximity Read ↗

Comparison of transgenic and adenovirus hACE2 mouse models for SARS-CoV-2 infectionSemantic proximity Read ↗

Comparison of Transgenic and Adenovirus hACE2 Mouse Models for SARS-CoV-2 InfectionSemantic proximity Read ↗

Simulation of COVID-19 Symptoms in a Genetically Engineered Mouse ModelSemantic proximity Read ↗

Animal models for SARS-Cov2/Covid19 research-A commentarySemantic proximity Read ↗

Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory diseaseSemantic proximity Read ↗

Mice transgenic for human angiotensin-converting enzyme 2 provide a model for SARS coronavirus infection.Semantic proximity Read ↗

Emerging SARS-CoV-2 variants expand species tropism to murinesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.