Article
Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies.
Scientific reports - 14 Mar 2018
Edington Collin D, Chen Wen Li Kelly, Geishecker Emily, Kassis Timothy, Soenksen Luis R, Bhushan Brij M, Freake Duncan, Kirschner Jared, Maass Christian, Tsamandouras Nikolaos, Valdez Jorge, Cook Christi D, Parent Tom, Snyder Stephen, Yu Jiajie, Suter Emily, Shockley Michael, Velazquez Jason, Velazquez Jeremy J, Stockdale Linda, Papps Julia P, Lee Iris, Vann Nicholas, Gamboa Mario, LaBarge Matthew E, Zhong Zhe, Wang Xin, Boyer Laurie A, Lauffenburger Douglas A, Carrier Rebecca L, Communal Catherine, Tannenbaum Steven R, Stokes Cynthia L, Hughes David J, Rohatgi Gaurav, Trumper David L, Cirit Murat, Griffith Linda G
Abstract excerpt
Microphysiological systems (MPSs) are in vitro models that capture facets of in vivo organ function through use of specialized culture microenvironments, including 3D matrices and microperfusion. Here, we report an approach to co-culture multiple different MPSs linked together physiologically on re-useable, open-system microfluidic platforms that are compatible with the quantitative study of a range of compounds,...
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