Article

Exosomal transmission of α-synuclein initiates Parkinson’s disease-like pathology

2021-05-11

Abstract excerpt

The intercellular transmission of α-synuclein is proposed to be involved in the pathogenesis of Parkinson’s disease (PD) 1 . Supporting this transmission hypothesis, α-synuclein has been identified to act as a prion 2 and has been found in cerebrospinal fluid (CSF), blood, and saliva 3 . However, the mechanism required to initiate the pathogenic spread of α-synuclein in the body that results in PD remains uncle...

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Literature Corpus work: b40ae59f-ab79-5826-bde9-26ec5fdf75a2
DOI: 10.1101/2021.05.10.443522

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