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Article

Parkinson's disease and alpha synuclein: is Parkinson's disease a prion-like disorder?

Movement disorders : official journal of the Movement Disorder Society - 1 Jan 2013

Olanow C Warren, Brundin Patrik

Abstract excerpt

Altered protein handling is thought to play a key role in the etiopathogenesis of Parkinson's disease (PD), as the disorder is characterized neuropathologically by the accumulation of intraneuronal protein aggregates (Lewy bodies and Lewy neurites). Attention has particularly focused on the α-synuclein protein, as it is the principal component of Lewy pathology. Moreover, point mutations in the α-synuclein gene...

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PMID: 23390095
DOI: 10.1002/mds.25373

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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