Article
Overexpression of alpha-synuclein at non-toxic levels increases dopaminergic cell death induced by copper exposure via modulation of protein degradation pathways.
Neurobiology of disease - 1 Sept 2015
Anandhan Annadurai, Rodriguez-Rocha Humberto, Bohovych Iryna, Griggs Amy M, Zavala-Flores Laura, Reyes-Reyes Elsa M, Seravalli Javier, Stanciu Lia A, Lee Jaekwon, Rochet Jean-Christophe, Khalimonchuk Oleh, Franco Rodrigo
Abstract excerpt
Gene multiplications or point mutations in alpha (α)-synuclein are associated with familial and sporadic Parkinson's disease (PD). An increase in copper (Cu) levels has been reported in the cerebrospinal fluid and blood of PD patients, while occupational exposure to Cu has been suggested to augment the risk to develop PD. We aimed to elucidate the mechanisms by which α-synuclein and Cu regulate dopaminergic cell...
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