Article

Intravenous gene transfer throughout the brain of infant Old World primates using AAV

2022-01-09

Abstract excerpt

Adeno-associated viruses (AAVs) can enable robust and safe gene delivery to the mammalian central nervous system (CNS). While the scientific community has developed numerous neurotropic AAV variants for systemic gene-transfer to the rodent brain, there are few AAVs that efficiently access the CNS of higher order primates. We describe here AAV.CAP-Mac, an engineered AAV variant that enables systemic, brain-wide gen...

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Literature Corpus work: 8ab32e65-ec9e-5530-b010-3da6fcb53c46
DOI: 10.1101/2022.01.08.475342

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