Article

Chronic inflammation suppresses del(5q)-like MDS HSCs via p53

2022-06-26

Abstract excerpt

Inflammation is associated with the pathogenesis of Myelodysplastic syndromes (MDS). Emerging evidence suggests that MDS hematopoietic stem and progenitor cells (HSPCs) exhibit an altered response to systemic low-grade inflammation, which contributes to their competitive advantage over wild-type HSPCs and ensuing hematopoietic defects. Deletion of the long arm of chromosome 5 (del(5q)) is the most common chromosom...

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Literature Corpus work: b3fdd5d4-b0b7-53d9-ae76-23b3ae2a6682
DOI: 10.1101/2022.06.22.497183

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