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Article

Activation of distinct inflammatory pathways in subgroups of LR-MDS

7 Jul 2023

Abstract excerpt

Aberrant innate immune signaling has been identified as a potential key driver of the complex pathophysiology of myelodysplastic neoplasms (MDS). This study of a large, clinically and genetically well-characterized cohort of treatment-naïve MDS patients confirms intrinsic activation of inflammatory pathways in general mediated by caspase-1, interleukin (IL)-1β and IL-18 in low-risk (LR)-MDS bone marrow and...

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PMID: 37420006
DOI: 10.1038/s41375-023-01949-2

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