Article

Moss BRCA2 lacking canonical DNA binding domain promotes efficient homologous recombination and binds to DNA

2025-03-19

Abstract excerpt

BRCA2 interacts with RAD51 and DMC1 recombinases and binds to single-stranded DNA (ssDNA), through its canonical DNA binding domain (DBD) to mediate homology-directed DNA repair (HDR). While the well-folded DBD is widely conserved in diverse eukaryotes, a non-canonical BRCA2 variant lacking this domain is found in Drosophila melanogaster . Whether such a non-canonical BRCA2 variant exists in other species is unkn...

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Literature Corpus work: b3fc709f-ee36-5add-8610-2b8801d78798
DOI: 10.1101/2025.03.19.644124

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