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Article

The COP1-ADA2b module mediates light regulation of DNA double-strand break repair in Arabidopsis.

Nature communications - 13 Mar 2026

Chen Li, Diao Liman, Ruan Jiaqi, Deng Yanli, Zhang Kai, Guan Yan, Li Ling, Liang Min, Peng Lina, Shi Jiayi, Zhang Shilong, Liu Minqing, Li Yupeng, Mao Zhilei, Wang Wenxiu, Yang Hong-Quan, Guo Tongtong

Abstract excerpt

DNA double-strand break (DSB) represents the most severe form of DNA damage, and both defective and hyperactive repair can compromise genome stability. It is known that blue light promotes DSB repair by cryptochromes (CRYs)-enhanced STRUCTURAL MAINTENANCE OF CHROMOSOME 5/6 (SMC5/6) complex recruitment via ALTERATION/DEFICIENCY IN ACTIVATION 2B (ADA2b). Here, we report a negative regulatory module consisting of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41820379
DOI: 10.1038/s41467-026-70673-z
PMCID: PMC13125681

Genes

COP1
SMC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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