Back to search

Article

Brain-wide structural and functional disruption in mice with oligodendrocyte specific <i>Nf1</i> deletion is rescued by inhibition of NOS

2020-04-01

Abstract excerpt

Neurofibromin gene ( NF1 ) mutation causes Neurofibromatosis type 1 (NF1), a disorder in which brain white matter deficits identified by neuroimaging are common, yet of unknown cellular etiology. In mice, Nf1 loss in adult oligodendrocyte causes myelin decompaction, and increases oligodendrocyte nitric oxide (NO) levels. Nitric oxide synthase (NOS) inhibitors rescue this pathology. Whether oligodendrocyte pathol...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b3e5c50a-4d1e-51c4-a241-49e1d4b06261
DOI
10.1101/2020.03.31.016089
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Brain-wide structural and functional disruption in mice with oligodendrocyte specific <i>Nf1</i> deletion is rescued by inhibition of NOSDOI 10.1101/2020.03.31.016089
Brain-wide structural and functional disruption in mice with oligodendrocyte-specific Nf1 deletion is rescued by inhibition of nitric oxide synthaseSemantic proximity
Current states in understanding oligodendroglia-mediated neurological issues in neurofibromatosis type 1 (NF1).Semantic proximity
Oligodendrocyte Nf1 Controls Aberrant Notch Activation and Regulates Myelin Structure and Behavior.Semantic proximity
Brain-wide mapping of oligodendrocyte organization and oligodendrogenesis across the murine lifespanSemantic proximity
Nf1 mutation disrupts activity-dependent oligodendroglial plasticity and motor learning in mice.Semantic proximity
A spatial imaging-transcriptomics paradigm for deciphering the molecular basis of microscopic MRI in the normal brain and Alzheimer’s diseaseSemantic proximity
Genetically perturbed myelin as a risk factor for neuroinflammation-driven axon degenerationSemantic proximity
Loss of function in the autism and learning disabilities associated gene <i>Nf1</i> disrupts corticocortical and corticostriatal functional connectivity in human and mouseSemantic proximity
Tbx1, a gene encoded in 22q11.2 copy number variant, is a link between alterations in fimbria myelination and cognitive speed in miceSemantic proximity
Impact of Pathogenic Variants of the Ras-MAPK Pathway on Major White Matter Tracts in the Human BrainSemantic proximity
Neurofibromin regulates corticostriatal inhibitory networks during working memory performanceSemantic proximity
Mouse Nr2f1 haploinsufficiency unveils new pathological mechanisms of a human optic atrophy syndromeSemantic proximity
Select a neighboring publication to make it the new centre.