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Article

Nf1 mutation disrupts activity-dependent oligodendroglial plasticity and motor learning in mice.

Nature neuroscience - 1 Aug 2024

Pan Yuan, Hysinger Jared D, Yalçın Belgin, Lennon James J, Byun Youkyeong Gloria, Raghavan Preethi, Schindler Nicole F, Anastasaki Corina, Chatterjee Jit, Ni Lijun, Xu Haojun, Malacon Karen, Jahan Samin M, Ivec Alexis E, Aghoghovwia Benjamin E, Mount Christopher W, Nagaraja Surya, Scheaffer Suzanne, Attardi Laura D, Gutmann David H, Monje Michelle

Abstract excerpt

Neurogenetic disorders, such as neurofibromatosis type 1 (NF1), can cause cognitive and motor impairments, traditionally attributed to intrinsic neuronal defects such as disruption of synaptic function. Activity-regulated oligodendroglial plasticity also contributes to cognitive and motor functions by tuning neural circuit dynamics. However, the relevance of oligodendroglial plasticity to neurological dysfunction...

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Identifiers

PMID: 38816530
DOI: 10.1038/s41593-024-01654-y
PMCID: PMC11303248

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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