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Article

Neurofibromin regulates corticostriatal inhibitory networks during working memory performance

12 Jul 2010

Abstract excerpt

Neurofibromatosis type I (NF1) is one of the most common single-gene causes of learning disabilities. Here, we use behavioral working memory probes and electrophysiological studies in a mouse model of NF1 (Nf1 heterozygous null mutants; Nf1(+/-)) to demonstrate that (i) Neurofibromin regulates prefrontal and striatal inhibitory networks, specifically activity-dependent GABA release and (ii) is required for...

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PMID: 20624961
DOI: 10.1073/pnas.1004829107

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