Article

RNA modifications and processing in cell homeostasis and in response to oxidative stress

2018-01-01

Abstract excerpt

RNA modifications and processing events are important modulators of global gene expression. Genomic mutations in the RNA methylase NSun2 and the alternative splicing factor Srsf2 are linked to neurological disorders and cancer in humans, respectively. NSun2 methylates cytosine-5 in most tRNAs and, to a lesser extent, other ncRNAs and mRNAs. Srsf2 is a critical component of the spliceosome and interacts with abunda...

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Literature Corpus work: a6d99ffe-09eb-5191-8319-d3d51efbdacf
DOI: 10.17863/cam.24559

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