Therapeutic targeting of SLC6A8 creatine transporter suppresses colon cancer progression and modulates human creatine levels.

doi:10.1126/sciadv.abi7511

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Article

Therapeutic targeting of SLC6A8 creatine transporter suppresses colon cancer progression and modulates human creatine levels.

Science advances - 8 Oct 2021

Kurth Isabel, Yamaguchi Norihiro, Andreu-Agullo Celia, Tian Helen S, Sridhar Subhasree, Takeda Shugaku, Gonsalves Foster C, Loo Jia Min, Barlas Afsar, Manova-Todorova Katia, Busby Robert, Bendell Johanna C, Strauss James, Fakih Marwan, McRee Autumn J, Hendifar Andrew E, Rosen Lee S, Cercek Andrea, Wasserman Robert, Szarek Michael, Spector Scott L, Raza Syed, Tavazoie Masoud F, Tavazoie Sohail F

Abstract excerpt

Colorectal cancer (CRC) is a leading cause of cancer mortality. Creatine metabolism was previously shown to critically regulate colon cancer progression. We report that RGX-202, an oral small-molecule SLC6A8 transporter inhibitor, robustly inhibits creatine import in vitro and in vivo, reduces intracellular phosphocreatine and ATP levels, and induces tumor apoptosis. RGX-202 suppressed CRC growth across KRAS...

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Identifiers

PMID: 34613776
DOI: 10.1126/sciadv.abi7511
PMCID: PMC8494442

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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