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Metabolic CRISPR screening identifies RPE as a key regulator of acquired enzalutamide resistance through FKBP5 destabilization in prostate cancer.

2026-05-14

Abstract excerpt

<title>Abstract</title> <p>Enzalutamide is a cornerstone therapy for castration-resistant prostate cancer (CRPC), yet acquired resistance remains a major clinical challenge. Although metabolic enzymes are increasingly recognized as modulators of therapeutic response, their specific roles—particularly their non-enzymatic functions—in sustaining enzalutamide resistance remain incompletely understood. In this study,...

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Literature Corpus work
45d53948-3e37-53a7-9a23-471afc8a9d2b
DOI
10.21203/rs.3.rs-9593389/v1
Open publication

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Metabolic CRISPR screening identifies RPE as a key regulator of acquired enzalutamide resistance through FKBP5 destabilization in prostate cancer.DOI 10.21203/rs.3.rs-9593389/v1
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