Article

Peptide-MHC-targeted retroviruses enable <i>in vivo</i> expansion and gene delivery to tumor-specific T cells

2024-09-22

Abstract excerpt

Tumor-infiltrating-lymphocyte (TIL) therapy has demonstrated that endogenous T cells can be harnessed to initiate an effective anti-tumor response. Despite clinical promise, current TIL production protocols involve weeks-long ex vivo expansions which can affect treatment efficacy. Therefore, additional tools are needed to engineer endogenous tumor-specific T cells to have increased potency while mitigating challe...

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Literature Corpus work: 3dcae8bc-1824-5039-8ac1-3be73ee6ba5d
DOI: 10.1101/2024.09.18.613594

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