Article

Upmodulation of Unfolded Protein Response and ER Stress-Related IL-23 Production in M1 Macrophages From Ankylosing Spondylitis Patients

2021-05-11

Abstract excerpt

<title>Abstract</title> <p>Background The inflammatory interleukin (IL)-23/IL-17 axis plays an important role in the pathogenesis of ankylosing spondylitis (AS), but with an unknown regulatory mechanism. The aim of this study was to investigate the role of endoplasmic reticulum (ER) stress and autophagy pathway in the expression of IL-23 in peripheral blood-derived macrophages in AS patients. Methods Peripheral...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b35b6a32-b0a9-5a99-a925-7dab41435cb2
DOI: 10.21203/rs.3.rs-499726/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Upmodulation of Unfolded Protein Response and ER Stress-Related IL-23 Production in M1 Macrophages From Ankylosing Spondylitis PatientsDOI 10.21203/rs.3.rs-499726/v1Read

TNFAIP3-DEPTOR complex regulates inflammasome secretion through autophagy in ankylosing spondylitis monocytesSemantic proximity Read

Aberrant expression of interleukin-23-regulated miRNAs in T cells from patients with ankylosing spondylitisSemantic proximity Read

Disease-associated polymorphisms in ERAP1 do not alter endoplasmic reticulum stress in patients with ankylosing spondylitis.Semantic proximity Read

Evaluation of ERAP1 gene single nucleotide polymorphisms in immunomodulation of pro-inflammatory and anti-inflammatory cytokines profile in ankylosing spondylitis.Semantic proximity Read

The regulatory mechanism and potential application of IL-23 in autoimmune diseasesSemantic proximity Read

The role of gut microbiota and IL-23/IL-17 pathway in ankylosing spondylitis immunopathogenesis: New insights and updates.Semantic proximity Read

The reciprocal regulation between autophagy and IL-22: implications for immunity and therapySemantic proximity Read

Inhibition of ERAP1 represses HLA-B27 free heavy chains expression on polarized macrophages and interrupts NK cells activation and function from ankylosing spondylitis.Semantic proximity Read

Association of the genetic variants in the Endoplasmic reticulum aminopeptidase 2 gene with ankylosing spondylitis susceptibilitySemantic proximity Read

Endoplasmic reticulum aminopeptidase 1 and interleukin-23 receptor in ankylosing spondylitis.Semantic proximity Read

Autophagy dysfunction may be involved in the pathogenesis of ankylosing spondylitisSemantic proximity Read

The integrated stress response promotes macrophage inflammation and migration in autoimmune diabetesSemantic proximity Read