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Article

Aberrant expression of interleukin-23-regulated miRNAs in T cells from patients with ankylosing spondylitis

21 Nov 2018

Abstract excerpt

BACKGROUND: Interleukin (IL)-23 can facilitate the differentiation of IL-17-producing helper T cells (Th17). The IL-23/IL-17 axis is known to play a key role in the immunopathogenesis of ankylosing spondylitis (AS). We hypothesized that the expression of microRNAs (miRNAs, miRs) would be regulated by IL-23 and that these miRNAs could participate in the immunopathogenesis of AS. METHODS: Expression profiles of...

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PMID: 30463609
DOI: 10.1186/s13075-018-1754-1

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