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Article

Resilience of BST-2/Tetherin structure to single amino acid substitutions

2018-11-26

Abstract excerpt

<h4>ABSTRACT</h4> Human Tetherin, also known as BST-2 or CD317, is a dimeric, extracellular membrane-bound protein that consists of N and C terminal membrane anchors connected by an extracellular domain. BST-2 is involved in binding enveloped viruses, such as HIV, and inhibiting viral release in addition to a role in NF-kB signaling. Viral tethering by Tetherin can be disrupted by the interaction with Vpu in HIV-...

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Literature Corpus work
b351e88c-24e0-5167-b3dd-b3438d9ce160
DOI
10.1101/479402
Open publication

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