Article

Cardiac MAO-A inhibition protects against catecholamine-induced ventricular arrhythmias via enhanced diastolic calcium control

2022-10-02

Abstract excerpt

<h4>Background</h4> People with clinical depression exhibit increased risk for cardiac arrhythmias that could be related to differences in catecholamine metabolism. Emerging studies have implicated a pathophysiologic role for monoamine oxidase (MAO-A), which catalyzes catecholamine metabolism in the heart. MAO-A is the pharmacological target of some classes of anti-depressants. Here, we investigated the relations...

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Literature Corpus work: b3330a75-8551-5438-99a6-386c256fecd7
DOI: 10.1101/2022.09.29.510139

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