Article
Sex and Gene Influence Arrhythmia Susceptibility in Murine Models of Calmodulinopathy.
Circulation. Arrhythmia and electrophysiology - 1 Sept 2023
Wren Lisa M, DeKeyser Jean-Marc, Barefield David Y, Hawkins Nicole A, McNally Elizabeth M, Kearney Jennifer A, Wasserstrom J Andrew, George Alfred L
Abstract excerpt
BACKGROUND: Pathogenic variants in genes encoding CaM (calmodulin) are associated with a life-threatening ventricular arrhythmia syndrome (calmodulinopathy). The in vivo consequences of CaM variants have not been studied extensively and there is incomplete understanding of the genotype-phenotype relationship for recurrent variants. We investigated effects of different factors on calmodulinopathy phenotypes using...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.