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Article

Pathogenesis of depression- and anxiety-like behavior in an animal model of hypertrophic cardiomyopathy.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jun 2017

Dossat Amanda M, Sanchez-Gonzalez Marcos A, Koutnik Andrew P, Leitner Stefano, Ruiz Edda L, Griffin Brittany, Rosenberg Jens T, Grant Samuel C, Fincham Francis D, Pinto Jose R, Kabbaj Mohamed

Abstract excerpt

Cardiovascular dysfunction is highly comorbid with mood disorders, such as anxiety and depression. However, the mechanisms linking cardiovascular dysfunction with the core behavioral features of mood disorder remain poorly understood. In this study, we used mice bearing a knock-in sarcomeric mutation, which is exhibited in human hypertrophic cardiomyopathy (HCM), to investigate the influence of HCM over the...

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Identifiers

PMID: 28235781
DOI: 10.1096/fj.201600955RR
PMCID: PMC5434648

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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