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Article

Cerebrovascular Claudin-5 Isoform Expression Correlates with Worsened Stroke Outcomes Following Thromboembolic Stroke

2025-08-18

Abstract excerpt

<h4>Background and Purpose</h4> Claudin-5 plays a crucial role in the maintenance of the blood-brain barrier (BBB) integrity through its role in endothelial tight junction formation. Alternative splicing of claudin-5 within the microvascular endothelium may modulate BBB structural and functional dynamics, potentially influencing neuronal damage and recovery following ischemic stroke. We hypothesized that ischemic...

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Literature Corpus work
b32a35ee-ce90-56d2-b102-e1c163717b9f
DOI
10.1101/2025.08.13.670217
Open publication

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Cerebrovascular Claudin-5 Isoform Expression Correlates with Worsened Stroke Outcomes Following Thromboembolic StrokeDOI 10.1101/2025.08.13.670217
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