Article

Extracellular vesicles from preeclampsia disrupt the blood-brain barrier via reduced claudin-5: potential role of vascular endothelial growth factor

2024-04-15

Abstract excerpt

<h4>Background</h4> Physiopathology of life-treating cerebrovascular complications in preeclampsia are yet unknown. We investigated whether disruption of the blood-brain barrier (BBB), generated using circulating small extracellular vesicles (sEVs) from women with preeclampsia or placentae cultured under hypoxic conditions, impairs the expression of tight junction proteins, such as claudin 5 (CLDN5), mediated by...

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Literature Corpus work: d839e6a7-54a4-5ac7-b972-be83c4099b1a
DOI: 10.1101/2024.04.10.588960

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