Article

Rescue of aberrant huntingtin palmitoylation ameliorates mutant huntingtin-induced toxicity

2021-03-28

Abstract excerpt

Huntington disease (HD) is a neurodegenerative disorder caused by a CAG expansion in the HTT gene that codes for an elongated polyglutamine tract in the huntingtin (HTT) protein. HTT is subject to multiple post-translational modifications (PTMs) that regulate its cellular function. Mutating specific PTM sites within mutant HTT (mHTT) in HD mouse models can modulate disease phenotypes, highlighting the key role of...

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Literature Corpus work: b322275d-b6aa-55c7-ada9-94449861bddc
DOI: 10.1101/2021.03.26.437210

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