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Article

Rescue of aberrant huntingtin palmitoylation ameliorates mutant huntingtin-induced toxicity.

Neurobiology of disease - 1 Oct 2021

Lemarié Fanny L, Caron Nicholas S, Sanders Shaun S, Schmidt Mandi E, Nguyen Yen T N, Ko Seunghyun, Xu Xiaohong, Pouladi Mahmoud A, Martin Dale D O, Hayden Michael R

Abstract excerpt

Huntington disease (HD) is a neurodegenerative disorder caused by a CAG expansion in the HTT gene that codes for an elongated polyglutamine tract in the huntingtin (HTT) protein. HTT is subject to multiple post-translational modifications (PTMs) that regulate its cellular function. Mutating specific PTM sites within mutant HTT (mHTT) in HD mouse models can modulate disease phenotypes, highlighting the key role of...

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PMID: 34390831
DOI: 10.1016/j.nbd.2021.105479

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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