Article
Molecular recognition of p53 and MDM2 by USP7/HAUSP.
Nature structural & molecular biology - 1 Mar 2006
Sheng Yi, Saridakis Vivian, Sarkari Feroz, Duan Shili, Wu Tianne, Arrowsmith Cheryl H, Frappier Lori
Abstract excerpt
The ubiquitin-specific protease, USP7, has key roles in the p53 pathway whereby it stabilizes both p53 and MDM2. We show that the N-terminal domain of USP7 binds two closely spaced 4-residue sites in both p53 and MDM2, falling between p53 residues 359-367 and MDM2 residues 147-159. Cocrystal structures with USP7 were determined for both p53 peptides and for one MDM2 peptide. These peptides bind the same surface...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.