Article

Potassium Channel Regulation Dysfunction as a Potential Driving Factor of Membrane Potential Disturbance in Restless Legs Syndrome

2025-07-18

Abstract excerpt

<h4>Background</h4> Restless legs syndrome (RLS) is a common neurological disorder whose pathophysiology remains poorly understood. Previous neuroelectrophysiological studies have found a widespread increase in neural excitability. Potassium channels are fundamental determinants of neuronal excitability through their control of resting membrane potential and firing threshold. Mendelian randomization (MR) analysis...

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Literature Corpus work: b3072763-be75-5ad6-ad06-ce7010d9c356
DOI: 10.1101/2025.07.17.25331613

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